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TOP is designed to address the long-term safety profile of TYSABRI, and the impact of a long term treatment with TYSABRI on disease activity and disability progression in particular. This is an epidemiological observational program for patients receiving TYSABRI with marketed use. Each patient will be followed for approximately 10 years. TOP will provide a comprehensive framework for assessing the long-term safety profile of TYSABRI and its impact on disease activity and disability progression.
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